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  • Superoxide Dismutase (SOD), Bovine Erythrocytes

    Superoxide dismutases are enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. Thus, they are an important antioxidant defense in nearly all cells exposed to oxygen.Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals and micro-organisms. They provide protection against damaging reactions ...

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  • Superoxide Dismutase Archives - Randox Laboratories

    2016-10-20 · Superoxide Dismutase. Superoxide is a by-product of oxygen metabolism and is one of the most damaging free radicals in the body as it can cause cell damage. Superoxide Dismutase (SOD) is an enzyme which catalyses the breakdown of superoxide into a …

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  • Up-Regulation of Superoxide Dismutase 2 in 3D Spheroid ...

    Umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) are accessible, available in abundance, and have been shown to be a promising source that can regenerate cartilage in patients with osteoarthritis or other orthopedic diseases. Recently, a three-dimensional (3D) cell culture system was developed to mimic the naive tissue microenvironment. However, the efficacy of cells generated ...

    Get Price
  • (PDF) Polymorphism of extracellular superoxide dismutase ...

    Extracellular-superoxide dismutase (EC-SOD) levels in sera divide into two discontinuous groups: a low-level group below 400 ng/ml and a high-level group above 400 ng/ml [Adachi, Nakamura, Yamada ...

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  • Wild-type Cu/Zn-superoxide dismutase is misfolded in ...

    2019-11-19 · A subset of familial forms of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene coding Cu/Zn-superoxide dismutase (SOD1). Mutant SOD1 proteins are susceptible to misfolding and abnormally accumulated in spinal cord, which is most severely affected in ALS. It, however, remains quite controversial whether misfolding of wild-type SOD1 is involved in more …

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  • (PDF) Molecular dynamics simulation of superoxide ...

    PDF Molecular dynamics simulations have been used to study the equilibrium distribution of a superoxide substrate molecule (O2−) in the channel to the... Find, read and cite all the research ...

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  • The beneficial effects of polyethylene glycol-superoxide ...

    2015-8-4 · The effects of polyethylene glycol-superoxide dismutase treatment on vitrified and warmed ovarian tissue in vitro Ovarian follicle integrity. Representative images of the histological analyses of the in vitro culture experiment is shown in Fig. 2.To evaluate the effects of PEG-SOD treatment on ovarian tissue integrity, ovarian follicle grading was performed.

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  • Neuroprotective Effects of PEP-1-Cu,Zn-SOD against ...

    2011-10-2 · A rabbit model of spinal cord ischemia has been introduced as a good model to investigate the pathophysiology of ischemia–reperfusion (I–R)-induced paraplegia. In the present study, we observed the effects of Cu,Zn-superoxide dismutase (SOD1) against ischemic damage in the ventral horn of L5–6 levels in the rabbit spinal cord. For this study, the expression vector PEP-1 was constructed ...

    Get Price
  • Reactive Oxygen Species in Metabolic and Inflammatory ...

    Reactive oxygen species (ROS) are well known for their role in mediating both physiological and pathophysiological signal transduction. Enzymes and subcellular compartments that typically produce ROS are associated with metabolic regulation, and diseases associated with metabolic dysfunction may be influenced by changes in redox balance.

    Get Price
  • The beneficial effects of polyethylene glycol-superoxide ...

    2015-8-4 · The effects of polyethylene glycol-superoxide dismutase treatment on vitrified and warmed ovarian tissue in vitro Ovarian follicle integrity. Representative images of the histological analyses of the in vitro culture experiment is shown in Fig. 2.To evaluate the effects of PEG-SOD treatment on ovarian tissue integrity, ovarian follicle grading was performed.

    Get Price
  • Up-Regulation of Superoxide Dismutase 2 in 3D Spheroid ...

    Umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) are accessible, available in abundance, and have been shown to be a promising source that can regenerate cartilage in patients with osteoarthritis or other orthopedic diseases. Recently, a three-dimensional (3D) cell culture system was developed to mimic the naive tissue microenvironment. However, the efficacy of cells generated ...

    Get Price
  • Therapeutic effect of lecithinized superoxide dismutase on ...

    2010-3-1 · Superoxide anion formation and glutathione metabolism of blood in patients with idiopathic pulmonary fibrosis. Biochem Mol Med 55: 66–70, 1995. Crossref PubMed Google Scholar; 46. Tsao C, Greene P, Odlind B, Brater DC. Pharmacokinetics of recombinant human superoxide dismutase in healthy volunteers. Clin Pharmacol Ther 50: 713–720, 1991.

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  • Aggregation and Cellular Toxicity of Pathogenic or Non ...

    2020-3-20 · Superoxide dismutase (SOD, EC 1.15.1.1) is an enzyme that converts superoxide (O 2 · −) radical into oxygen (O 2) and hydrogen peroxide (H 2 O 2) 32. There are three isoforms, known as SOD1 ...

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  • Neuroprotective Effects of PEP-1-Cu,Zn-SOD against ...

    2011-10-2 · A rabbit model of spinal cord ischemia has been introduced as a good model to investigate the pathophysiology of ischemia–reperfusion (I–R)-induced paraplegia. In the present study, we observed the effects of Cu,Zn-superoxide dismutase (SOD1) against ischemic damage in the ventral horn of L5–6 levels in the rabbit spinal cord. For this study, the expression vector PEP-1 was constructed ...

    Get Price
  • Strategies for Reducing or Preventing the Generation of ...

    2011-12-10 · These will dismutase to H 2 O 2 that can enter cells and react with superoxide or reduced metal ions to form highly damaging hydroxyl radicals . The presence of redox cycling metal ions with antioxidants might result in a synergistic effect, resulting in an …

    Get Price
  • Syringaresinol Reverses Age-Related Skin Atrophy by ...

    2018-10-26 · Aging is characterized by accumulation of chronic and irreversible oxidative damage, chronic inflammation, and organ dysfunction. Superoxide dismutase (SOD) serves as a major enzyme for cellular superoxide radical metabolism and physiologically regulates cellular redox balance throughout the body. Copper/zinc superoxide dismutase–deficient (SOD1–/–) mice showed diverse phenotypes ...

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  • Frontiers

    Cataract is the leading reason of blindness worldwide and is defined by the presence of any lens opacities or loss of transparency. The most common symptoms of cataract are impaired vision, decreased contrast sensitivity, color disturbance, and glare. Oxidative stress is among the main mechanisms involved in the development of age-related cataract. Surgery through …

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  • Reactive Oxygen Species in Metabolic and Inflammatory ...

    Reactive oxygen species (ROS) are well known for their role in mediating both physiological and pathophysiological signal transduction. Enzymes and subcellular compartments that typically produce ROS are associated with metabolic regulation, and diseases associated with metabolic dysfunction may be influenced by changes in redox balance.

    Get Price
  • Role of Catalase in Oxidative Stress- and Age-Associated ...

    2019-11-11 · Reactive species produced in the cell during normal cellular metabolism can chemically react with cellular biomolecules such as nucleic acids, proteins, and lipids, thereby causing their oxidative modifications leading to alterations in their compositions and potential damage to their cellular activities. Fortunately, cells have evolved several antioxidant defense mechanisms (as metabolites ...

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  • Superoxide dismutase is regulated by LAMMER kinase in ...

    2008-12-24 · INTRODUCTION. The antioxidant defense enzyme, superoxide dismutase (SOD), plays a critical role in the prevention of damage by reactive oxygen species (ROS) and the in vitro activation of SOD can increase differentiation, decrease cell proliferation [] and in Drosophila melanogaster loss of SOD1 causes early mortality [].Two SOD genes are found in all organisms, including bacteria [].

    Get Price
  • Up-Regulation of Superoxide Dismutase 2 in 3D Spheroid ...

    Umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) are accessible, available in abundance, and have been shown to be a promising source that can regenerate cartilage in patients with osteoarthritis or other orthopedic diseases. Recently, a three-dimensional (3D) cell culture system was developed to mimic the naive tissue microenvironment. However, the efficacy of cells generated ...

    Get Price
  • Strategies for Reducing or Preventing the Generation of ...

    2011-12-10 · These will dismutase to H 2 O 2 that can enter cells and react with superoxide or reduced metal ions to form highly damaging hydroxyl radicals . The presence of redox cycling metal ions with antioxidants might result in a synergistic effect, resulting in an …

    Get Price
  • Neuroprotective Effects of PEP-1-Cu,Zn-SOD against ...

    2011-10-2 · A rabbit model of spinal cord ischemia has been introduced as a good model to investigate the pathophysiology of ischemia–reperfusion (I–R)-induced paraplegia. In the present study, we observed the effects of Cu,Zn-superoxide dismutase (SOD1) against ischemic damage in the ventral horn of L5–6 levels in the rabbit spinal cord. For this study, the expression vector PEP-1 was constructed ...

    Get Price
  • KoreaMed Synapse

    2012-3-22 · The generation of superoxide was measured with a microplate reader using modified cytochrome c reduction [29,30]. The reactive solution was prepared by mixing 160 µM cytochrome c (Sigma) and 100 U/mL superoxide dismutase (Sigma), and …

    Get Price
  • Temperature stability of Poly-[hemoglobin-superoxide ...

    2018-7-21 · 1 Temperature stability of Poly-[hemoglobin-superoxide dismutase–catalase- carbonic anhydrase] in the form of a solution or in the lyophilized form during storage at -80 oC, 4 oC, 25 oC and 37 oC or pasteurization at 70 oC. (This is the pre-peer reviewed version which has been published in final form at Journal Artificial Cells, Nanomedicine and Biotechnology 44:41-47, 2016)

    Get Price
  • A Specific Melon Concentrate Exhibits Photoprotective ...

    2018-3-31 · 2.1. Preparation and Characterization of the Melon Concentrate. SODB ® (Bionov, Avignon, France) is a dried melon juice concentrate particularly rich in superoxide dismutase (SOD), which results from a patented process. Briefly, the pulp of a specific proprietary and non-GMO melon variety (Cucumis melo L.) is separated from skin and seeds and crushed before centrifugation.

    Get Price
  • Nanoparticles for targeted delivery of antioxidant …

    2019-7-23 · Superoxide dismutase from bovine liver (3,000u/mg, #574594) was obtained from Calbiochem (Gibbstown, NJ, USA). Anti-Glutamate Receptor NMDAR1 (NR1) IgG produced in rabbit (#G8913) and nonspecific rabbit anti-bovine IgG (whole molecule) (#B5645) were purchased from Sigma-Aldrich (St Louis, MO, USA). According to manufacturer's information sheet,

    Get Price
  • Diversity and Antimicrobial Resistance in the ...

    2021-1-5 · Blood & Tissue Kit (Qiagen Korea Ltd., Seoul, Korea), according to the manufacturer's protocol. The 16S rRNA gene was amplified using universal primers 27F and 1492R, and the amplicons were sequenced using universal primers 785F and 907R (Table S2). Overall, the PCR amplifications in this study were performed using the Maxime PCR PreMix

    Get Price
  • (PDF) An iron-superoxide dismutase antigen-based ...

    Further, our Fe-SOD-based ELISA and western blot results provide evidence that both Le. braziliensis and Fe-SODe, excreted iron-superoxide dismutase.1 þ þ 40 þ 4 þ 41 þ þ 5 þ 42 þ þ 8 þ þ þ 46 þ þ 10 þ 48 þ 11 þ þ þ 49 þ 13 þ þ þ 50 þ þ 14 þ 51 þ þ Subtotal 0 0 0 0 6 5 1 3 52 þ þ þ þ Celestun 53 þ þ þ þ 17 þ ...

    Get Price
  • Superoxide dismutase is regulated by LAMMER kinase in ...

    2008-12-24 · INTRODUCTION. The antioxidant defense enzyme, superoxide dismutase (SOD), plays a critical role in the prevention of damage by reactive oxygen species (ROS) and the in vitro activation of SOD can increase differentiation, decrease cell proliferation [] and in Drosophila melanogaster loss of SOD1 causes early mortality [].Two SOD genes are found in all organisms, including bacteria [].

    Get Price
  • Up-Regulation of Superoxide Dismutase 2 in 3D Spheroid ...

    Umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) are accessible, available in abundance, and have been shown to be a promising source that can regenerate cartilage in patients with osteoarthritis or other orthopedic diseases. Recently, a three-dimensional (3D) cell culture system was developed to mimic the naive tissue microenvironment. However, the efficacy of cells generated ...

    Get Price
  • Strategies for Reducing or Preventing the Generation of ...

    2011-12-10 · These will dismutase to H 2 O 2 that can enter cells and react with superoxide or reduced metal ions to form highly damaging hydroxyl radicals . The presence of redox cycling metal ions with antioxidants might result in a synergistic effect, resulting in an …

    Get Price
  • Neuroprotective Effects of PEP-1-Cu,Zn-SOD against ...

    2011-10-2 · A rabbit model of spinal cord ischemia has been introduced as a good model to investigate the pathophysiology of ischemia–reperfusion (I–R)-induced paraplegia. In the present study, we observed the effects of Cu,Zn-superoxide dismutase (SOD1) against ischemic damage in the ventral horn of L5–6 levels in the rabbit spinal cord. For this study, the expression vector PEP-1 was constructed ...

    Get Price
  • KoreaMed Synapse

    2012-3-22 · The generation of superoxide was measured with a microplate reader using modified cytochrome c reduction [29,30]. The reactive solution was prepared by mixing 160 µM cytochrome c (Sigma) and 100 U/mL superoxide dismutase (Sigma), and …

    Get Price
  • Temperature stability of Poly-[hemoglobin-superoxide ...

    2018-7-21 · 1 Temperature stability of Poly-[hemoglobin-superoxide dismutase–catalase- carbonic anhydrase] in the form of a solution or in the lyophilized form during storage at -80 oC, 4 oC, 25 oC and 37 oC or pasteurization at 70 oC. (This is the pre-peer reviewed version which has been published in final form at Journal Artificial Cells, Nanomedicine and Biotechnology 44:41-47, 2016)

    Get Price
  • A Specific Melon Concentrate Exhibits Photoprotective ...

    2018-3-31 · 2.1. Preparation and Characterization of the Melon Concentrate. SODB ® (Bionov, Avignon, France) is a dried melon juice concentrate particularly rich in superoxide dismutase (SOD), which results from a patented process. Briefly, the pulp of a specific proprietary and non-GMO melon variety (Cucumis melo L.) is separated from skin and seeds and crushed before centrifugation.

    Get Price
  • Nanoparticles for targeted delivery of antioxidant …

    2019-7-23 · Superoxide dismutase from bovine liver (3,000u/mg, #574594) was obtained from Calbiochem (Gibbstown, NJ, USA). Anti-Glutamate Receptor NMDAR1 (NR1) IgG produced in rabbit (#G8913) and nonspecific rabbit anti-bovine IgG (whole molecule) (#B5645) were purchased from Sigma-Aldrich (St Louis, MO, USA). According to manufacturer's information sheet,

    Get Price
  • Diversity and Antimicrobial Resistance in the ...

    2021-1-5 · Blood & Tissue Kit (Qiagen Korea Ltd., Seoul, Korea), according to the manufacturer's protocol. The 16S rRNA gene was amplified using universal primers 27F and 1492R, and the amplicons were sequenced using universal primers 785F and 907R (Table S2). Overall, the PCR amplifications in this study were performed using the Maxime PCR PreMix

    Get Price
  • (PDF) An iron-superoxide dismutase antigen-based ...

    Further, our Fe-SOD-based ELISA and western blot results provide evidence that both Le. braziliensis and Fe-SODe, excreted iron-superoxide dismutase.1 þ þ 40 þ 4 þ 41 þ þ 5 þ 42 þ þ 8 þ þ þ 46 þ þ 10 þ 48 þ 11 þ þ þ 49 þ 13 þ þ þ 50 þ þ 14 þ 51 þ þ Subtotal 0 0 0 0 6 5 1 3 52 þ þ þ þ Celestun 53 þ þ þ þ 17 þ ...

    Get Price
  • Superoxide dismutase is regulated by LAMMER kinase in ...

    2008-12-24 · INTRODUCTION. The antioxidant defense enzyme, superoxide dismutase (SOD), plays a critical role in the prevention of damage by reactive oxygen species (ROS) and the in vitro activation of SOD can increase differentiation, decrease cell proliferation [] and in Drosophila melanogaster loss of SOD1 causes early mortality [].Two SOD genes are found in all organisms, including bacteria [].

    Get Price
  • Up-Regulation of Superoxide Dismutase 2 in 3D Spheroid ...

    Umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) are accessible, available in abundance, and have been shown to be a promising source that can regenerate cartilage in patients with osteoarthritis or other orthopedic diseases. Recently, a three-dimensional (3D) cell culture system was developed to mimic the naive tissue microenvironment. However, the efficacy of cells generated ...

    Get Price
  • Strategies for Reducing or Preventing the Generation of ...

    2011-12-10 · These will dismutase to H 2 O 2 that can enter cells and react with superoxide or reduced metal ions to form highly damaging hydroxyl radicals . The presence of redox cycling metal ions with antioxidants might result in a synergistic effect, resulting in an …

    Get Price
  • Neuroprotective Effects of PEP-1-Cu,Zn-SOD against ...

    2011-10-2 · A rabbit model of spinal cord ischemia has been introduced as a good model to investigate the pathophysiology of ischemia–reperfusion (I–R)-induced paraplegia. In the present study, we observed the effects of Cu,Zn-superoxide dismutase (SOD1) against ischemic damage in the ventral horn of L5–6 levels in the rabbit spinal cord. For this study, the expression vector PEP-1 was constructed ...

    Get Price
  • KoreaMed Synapse

    2012-3-22 · The generation of superoxide was measured with a microplate reader using modified cytochrome c reduction [29,30]. The reactive solution was prepared by mixing 160 µM cytochrome c (Sigma) and 100 U/mL superoxide dismutase (Sigma), and …

    Get Price
  • Temperature stability of Poly-[hemoglobin-superoxide ...

    2018-7-21 · 1 Temperature stability of Poly-[hemoglobin-superoxide dismutase–catalase- carbonic anhydrase] in the form of a solution or in the lyophilized form during storage at -80 oC, 4 oC, 25 oC and 37 oC or pasteurization at 70 oC. (This is the pre-peer reviewed version which has been published in final form at Journal Artificial Cells, Nanomedicine and Biotechnology 44:41-47, 2016)

    Get Price
  • A Specific Melon Concentrate Exhibits Photoprotective ...

    2018-3-31 · 2.1. Preparation and Characterization of the Melon Concentrate. SODB ® (Bionov, Avignon, France) is a dried melon juice concentrate particularly rich in superoxide dismutase (SOD), which results from a patented process. Briefly, the pulp of a specific proprietary and non-GMO melon variety (Cucumis melo L.) is separated from skin and seeds and crushed before centrifugation.

    Get Price
  • Nanoparticles for targeted delivery of antioxidant …

    2019-7-23 · Superoxide dismutase from bovine liver (3,000u/mg, #574594) was obtained from Calbiochem (Gibbstown, NJ, USA). Anti-Glutamate Receptor NMDAR1 (NR1) IgG produced in rabbit (#G8913) and nonspecific rabbit anti-bovine IgG (whole molecule) (#B5645) were purchased from Sigma-Aldrich (St Louis, MO, USA). According to manufacturer's information sheet,

    Get Price
  • Diversity and Antimicrobial Resistance in the ...

    2021-1-5 · Blood & Tissue Kit (Qiagen Korea Ltd., Seoul, Korea), according to the manufacturer's protocol. The 16S rRNA gene was amplified using universal primers 27F and 1492R, and the amplicons were sequenced using universal primers 785F and 907R (Table S2). Overall, the PCR amplifications in this study were performed using the Maxime PCR PreMix

    Get Price
  • (PDF) An iron-superoxide dismutase antigen-based ...

    Further, our Fe-SOD-based ELISA and western blot results provide evidence that both Le. braziliensis and Fe-SODe, excreted iron-superoxide dismutase.1 þ þ 40 þ 4 þ 41 þ þ 5 þ 42 þ þ 8 þ þ þ 46 þ þ 10 þ 48 þ 11 þ þ þ 49 þ 13 þ þ þ 50 þ þ 14 þ 51 þ þ Subtotal 0 0 0 0 6 5 1 3 52 þ þ þ þ Celestun 53 þ þ þ þ 17 þ ...

    Get Price