Thieme E-Journals - Planta Medica / Full Text
Silybin, an active flavonolignan of milk thistle (Silybum marianum), was shown to be a potent inhibitor of UGT1A1 (IC 50 of 1.4 µM) and other UGTs with less potency (IC 50 range = 28–75 µM) . Silybin also inhibited CYP3A4 activity in vitro (K i range = 5–160 µM) .
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